JAMA 100 Years Ago Section Editor: Jennifer Reiling, Assistant Editor.
Recently the work of Kramer, Gèrard, Baldwin and Lichtwitz on the origin of gallstones was reviewed in these columns.1 Kramer was able to produce artificial gallstones in the test-tube by inoculating pure bile with E. coli and B. typhosus. . . . He did not obtain the constituents of stones from bile inoculated with staphylococcus nor from sterile bile on long standing.
Continuing the work along these lines, Bacmeister2 has added some new facts which are interesting and which he uses to explain the properties of gallstones and their occurrence under certain conditions. He found that B. pyocyaneus and B. proteus, as well as B. coli and B. typhosus, cause a precipitation of cholesterin, and also that on long standing the cholesterin separates out in sterile bile. In filtered bile it does so less rapidly than in unfiltered bile.
FURTHER OBSERVATIONS ON THE GENESIS OF GALLSTONES.. JAMA. 2008;299(13):1616. doi:10.1001/jama.299.13.1616