The amyloid plaques found in the brain of patients with Alzheimer disease may form much more rapidly than previously thought. Using an advanced microscopic imaging technique called longitudinal in vivo multiphoton microscopy to examine brain tissue in mouse models of the disease, researchers from the MassGeneral Institute for Neurodegenerative Disease in Charlestown, Mass, found that plaques form quickly over a 24-hour period (Meyer-Luehmann M et al. Nature. 2008;451:720-724). They also observed that within 1 to 2 days of a new plaque's appearance, microglia are activated and recruited to the site.
Hampton T. Alzheimer Plaques. JAMA. 2008;299(13):1533. doi:10.1001/jama.299.13.1533-b