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Clinical Crossroads
Clinician's Corner
April 2, 2008

A 21-Year-Old Man With Chronic Pancreatitis

Author Affiliations

Author Affiliations: Dr Callery is Associate Professor of Surgery, Harvard Medical School, and Chief, Division of General Surgery, Beth Israel Deaconess Medical Center, and Dr Freedman is Associate Professor of Medicine, Harvard Medical School, Medical Director, Clinical Research Affairs, and Director, Pancreas Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

JAMA. 2008;299(13):1588-1594. doi:10.1001/jama.299.9.jrr80001
Abstract

Chronic pancreatitis is a disease for which the diagnosis may be difficult to ascertain and the treatments are limited. Using the case of a 21-year-old man who has had recurrent episodes of epigastric pain since age 10 years and was ultimately diagnosed as having idiopathic pancreatitis complicated by pancreatic duct stones, we discuss the evaluation and treatment of chronic pancreatitis. Diagnosis is based on thorough history taking, physical examination, and carefully selected imaging studies. Etiologies may be structural or nonstructural; genes predisposing to chronic pancreatitis have been identified. An evidence-based approach to treatment is limited by a paucity of randomized controlled trials. We address the patient's concerns regarding chronic pancreatitis, including what he should expect over the next several years, whether endoscopic or surgical therapies should be considered, and whether there are any cures.

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