To the Editor: In the report of their randomized controlled trial, Dr Wu and colleagues1 concluded that lifestyle intervention and metformin alone and in combination demonstrated efficacy for weight reduction in patients taking antipsychotic medications. The rationale for their study was based on the assumption that weight loss in this population is beneficial to health and that the “induction of obesity by antipsychotic agents” is linked with greater morbidity and mortality.
Llewellyn DJ, Naughton F. Antipsychotic-Induced Weight Gain in Patients With Schizophrenia. JAMA. 2008;299(16):1898-1900. doi:10.1001/jama.299.16.1898-b