To the Editor: Dr Emmelot-Vonk and colleagues1 reported the findings of a randomized, placebo-controlled trial of 237 older men treated with oral testosterone supplementation for 6 months. This is an area of clinical importance for physicians prescribing testosterone to older men in whom the efficacy and safety of androgen administration remains unclear. However, there are methodological issues that make some of the null results of this trial difficult to interpret and place into clinical context.
Page S, Matsumoto AM. Effects of Testosterone Therapy in Older Men. JAMA. 2008;299(16):1900-1901. doi:10.1001/jama.299.16.1900-a