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Lab Reports
June 4, 2008

Capturing Flu Antibodies

JAMA. 2008;299(21):2500. doi:10.1001/jama.299.21.2500-a

A new method for creating human monoclonal antibodies against infectious disease pathogens could prove effective for protecting the public against a future pandemic influenza strain (Wrammert J et al. Nature. 10.1038/nature06890 [published online ahead of print April 30, 2008]).

Led by investigators at the Emory University School of Medicine in Atlanta and the Oklahoma Medical Research Foundation in Oklahoma City, researchers isolated antibody-secreting plasma cells from volunteers' blood after seasonal influenza vaccination and cloned the antibody genes from these cells. Within 7 days of vaccination, as much as 80% of the individuals' antibody-secreting plasma cells recognized the strain of virus used in the vaccine.

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