A new method for creating human monoclonal antibodies against infectious disease pathogens could prove effective for protecting the public against a future pandemic influenza strain (Wrammert J et al. Nature. 10.1038/nature06890 [published online ahead of print April 30, 2008]).
Led by investigators at the Emory University School of Medicine in Atlanta and the Oklahoma Medical Research Foundation in Oklahoma City, researchers isolated antibody-secreting plasma cells from volunteers' blood after seasonal influenza vaccination and cloned the antibody genes from these cells. Within 7 days of vaccination, as much as 80% of the individuals' antibody-secreting plasma cells recognized the strain of virus used in the vaccine.
Hampton T. Capturing Flu Antibodies. JAMA. 2008;299(21):2500. doi:10.1001/jama.299.21.2500-a