Nanoparticles bearing inhibitory RNA may have potential for stopping premalignant breast lesions from progressing to invasive cancers, report scientists from several Boston-based institutions (Brock A et al. Sci Transl Med. 2014;6:217ra2.)
Using computer analyses to screen gene expression patterns and identify changes that occur during tumorigenesis in mammary tissue, the researchers identified the HoxA1 gene as a driver of early breast cancer progression. Past work also suggests that this gene might play an important role in breast cancer development.
Hampton T. Inhibitory RNA Takes Aim at Halting Breast Cancer Progression. JAMA. 2014;311(5):456. doi:10.1001/jama.2014.288