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Lab Reports
February 5, 2014

Inhibitory RNA Takes Aim at Halting Breast Cancer Progression

Author Affiliations

Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;311(5):456. doi:10.1001/jama.2014.288

Nanoparticles bearing inhibitory RNA may have potential for stopping premalignant breast lesions from progressing to invasive cancers, report scientists from several Boston-based institutions (Brock A et al. Sci Transl Med. 2014;6[217]:217ra2.)

Using computer analyses to screen gene expression patterns and identify changes that occur during tumorigenesis in mammary tissue, the researchers identified the HoxA1 gene as a driver of early breast cancer progression. Past work also suggests that this gene might play an important role in breast cancer development.

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