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The Medical Letter on Drugs and Therapeutics
February 5, 2014

Tablet Splitting

Author Affiliations

Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;311(5):521. doi:10.1001/jama.2014.208

Breaking drug tablets in half is a common practice.1 Since our last article on this subject, some new data have become available.2

Tablets are sometimes split to achieve an intermediate dose between marketed strengths and, when 2 tablet strengths cost the same, as they often do, splitting the higher strength saves money.

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