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June 11, 2008

MicroRNA Expression in Colon Adenocarcinoma

JAMA. 2008;299(22):2628-2629. doi:10.1001/jama.299.22.2628-a

To the Editor: Dr Schetter and colleagues1 demonstrated that high microRNA miR-21 expression in colon adenocarcinoma tissue was associated with a low survival rate and resistance to chemotherapy. Table 2 of their article listed microRNAs with significantly higher expression in tumors, including miR-335. Recently, miR-335 was reported to be a metastasis-suppressor microRNA in breast cancer, indicating that miR-335 may prevent tumor progression.2 It is possible that miR-335 has an opposite function in breast cancer vs colon cancer.3 The expression of miR-335 might be secondary during inhibition of tumor metastasis. We would be interested in the authors' interpretation of these differing findings.

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