In Reply: We appreciate the comments of Drs Anghelescu and Regen regarding the TORDIA study. With respect to the switching strategy, we chose a conservative approach in this adolescent population rather than extrapolate from a strategy used in adults. Because our study was not placebo-controlled, the results from TORDIA cannot directly address the question of suicidality and antidepressant use. However, prospective studies specifically designed to address this issue are warranted.
Brent D, Wagner KD. SSRI Tapering and Suicidal Ideation in the TORDIA Study for Treatment of Depressed Adolescents—Reply. JAMA. 2008;299(23):2745-2746. doi:10.1001/jama.299.23.2746-a