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Lab Reports
July 2, 2008

Tomatoes and Cancer

JAMA. 2008;300(1):33. doi:10.1001/jama.300.1.33-b

New research reveals additional clues to the mechanism behind tomatoes' known protective effect against prostate cancer (Mossine VV et al. Cancer Res. 2008;68[11]:4384-4391).

Investigators at the University of Missouri-Columbia, and colleagues demonstrated that FruHis, a carbohydrate derivative present in dehydrated tomato products, exerts this effect.

Rats were divided into groups of 20 and fed a control diet or a diet that included tomato paste, tomato powder, or tomato paste plus additional FruHis. All animals were then treated with N-nitroso-N-methylurea and testosterone to induce prostate carcinogenesis.

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