In Reply: In response to Dr Oba and Drs Borges and colleagues, we agree that the ability to identify those patients with ALI and ARDS who are most likely to benefit from an open-lung approach is a laudable goal. We hope that our experimental approach to PEEP titration, while taking into consideration lung protection, oxygenation, hemodynamics, and barotrauma, will be improved on in the future with more sophisticated methods of individualizing ventilatory management.
Meade MO, Stewart TE. Ventilation Strategies for Acute Lung Injury and Acute Respiratory Distress Syndrome—Reply. JAMA. 2008;300(1):39-43. doi:10.1001/jama.300.1.42-a