To the Editor: Dr Bhattacharyya and colleagues1 described a strong link between genetic determinants and activity of paraoxonase 1 (PON1), oxidative stress, all-cause mortality, and major adverse coronary events. The authors suggested that their findings support the hypothesis that fewer oxidized lipids in the low-density lipoprotein cholesterol particle would be of clinical benefit, an idea for which I am not aware of any trial support.
Vos E. Homocysteine Levels, Paraoxonase 1 (PON1) Activity, and Cardiovascular Risk. JAMA. 2008;300(2):168-169. doi:10.1001/jama.300.2.168