A previously unrecognized group of stem cells can give rise to cardiomyocytes (Zhou B et al. Nature. 2008;454:109-113). These stem cells, located in the epicardium at the surface of the heart, might have potential for cardiac regeneration and repair.
Scientists at Children's Hospital Boston found that heart muscle cells can be derived from a cardiac progenitor identifiable via its expression of Wt1, a gene that encodes a protein that controls expression of other genes.
Hampton T. Heart Stem Cell Source. JAMA. 2008;300(9):1016. doi:10.1001/jama.300.9.1016-b