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Lab Reports
September 3, 2008

Cancer Drug Target

JAMA. 2008;300(9):1016. doi:10.1001/jama.300.9.1016-c

Researchers have blocked the development of prostate tumors in cancer-prone mice by disabling a molecule that is part of a cellular signaling network disrupted in several common cancers (Jia S et al. Nature. 10.1038/nature07091 [published online ahead of print June 25, 2008]). The molecule, p110beta, and a counterpart, p110alpha, are different forms of an enzyme called phosphatidylinositol-3-OH kinase PI(3)K. When activated by growth factor receptors, PI(3)K turns on a sequence of genes and proteins that causes cells to divide and grow.

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