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September 3, 2008

Clopidogrel Treatment and the MEND-CABG II Trial—Reply

JAMA. 2008;300(9):1021-1022. doi:10.1001/jama.300.9.1021-b

In Reply: We share the interest of Dr Oh and colleagues in the use of clopidogrel and its relationship to both hemorrhagic and ischemic outcomes in patients undergoing CABG surgery. As they point out, the risks and benefits of clopidogrel before and after CABG surgery are controversial and poorly understood.1 Current guidelines from the American College of Cardiology and American Heart Association recommend discontinuing clopidogrel several days before CABG surgery and restarting it postoperatively for up to a year in patients with recent acute coronary syndromes.2

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