Scientists in England and the Netherlands have identified a protein that appears to identify patients with colorectal cancer associated with tumor progression and a poorer prognosis (Willis ND et al. PLoS One. 2008;3:e2988). The finding could help clinicians identify patients who might benefit from more aggressive treatment.
The researchers screened an archive of colorectal cancer samples and normal colon tissue for a stem cell marker protein called lamin A. They found that lamin A is expressed in colonic stem cells and that patients with tumors expressing lamin A had significantly worse prognosis than those with tumors not expressing the protein.
Stephenson J. Colon Cancer Biomarker. JAMA. 2008;300(11):1291. doi:10.1001/jama.300.11.1291-a