Like a battery that loses power over time, some medications become ineffective after prolonged use. Of course, the drugs themselves do not change; rather, some change in the status quo, such as the emergence of resistance in a pathogen or a cancer cell, subverts the drug's effects.
Now a study by researchers at Stanford University in Stanford, Calif, demonstrates a particularly promising new strategy for retaining drugs' efficacy in the face of such disease-related resistance (Thorne SH et al. Proc Natl Acad Sci U S A. 2008;105:12128-12133).
Hampton T. Researchers Devise Innovative Method to Overcome Cancer-Related Drug Resistance. JAMA. 2008;300(13):1507. doi:10.1001/jama.300.13.1507