To the Editor: In a randomized, placebo-controlled trial of the preventive use of the SSRI escitalopram in poststroke depression, Dr Robinson and colleagues1 classified the study by Rasmussen et al2 in the group of trials that have failed to show a significant effect of SSRIs over placebo in preventing poststroke depression. This is not correct.
Rasmussen A, Hanash JA, Bech P. Escitalopram, Problem-Solving Therapy, and Poststroke Depression. JAMA. 2008;300(15):1757-1759. doi:10.1001/jama.300.15.1758-a