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Health Agencies Update
October 22 2008

Genes and Kidney Disease

JAMA. 2008;300(16):1876. doi:10.1001/jama.300.16.1876-c

Variations in a particular gene may account for some of the increased risk of kidney disease among blacks, according to 2 independent studies.

In 1 study, scientists from the National Institutes of Health (NIH) scanned the genome of 190 blacks with focal segmental glomerulosclerosis (FSGS) and 222 blacks without the disorder (Kopp JB et al. Nat Genet. 101038/ng.226 [published online ahead of print on September 14, 2008]). FSGS is a disorder that leads to kidney failure in half of all patients in about 10 years. Some of the FSGS cases were associated with HIV infection. The scientists found that persons with variations in the MYH9 gene were more likely to develop the disorder.

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