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Lab Reports
November 5, 2008

Diabetes and Bacteria

JAMA. 2008;300(17):1989. doi:10.1001/jama.2008.530

New research indicates that intestinal bacteria may play a role in preventing the development of type 1 diabetes (Wen L et al. Nature. 10.1038/nature07336 [published online ahead of print September 21, 2008]).

Investigators at the University of Chicago, Yale University in New Haven, Conn, and other institutions made this potential link through experiments with genetically modified diabetic mice that lack a part of the immune system that responds to bacteria. Specifically, the mice do not produce a protein called MyD88, which relays signals from multiple innate immune receptors that recognize microbial stimuli.

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