[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Lab, Field, and Clinic
November 5, 2008

Adult Pancreatic Cells “Reprogrammed” Into Rarer Insulin-Producing Cells

JAMA. 2008;300(17):1988. doi:10.1001/jama.2008.534

Researchers have reprogrammed adult exocrine cells from the pancreas into the much different and rarer insulin-producing beta cells, a feat that could lead to improvements in diabetes care (Zhou Q et al. Nature. 10.1038/nature07314 [published online ahead of print August 27, 2008]).

While the experiments were done in mice, they provide a proof of concept that relatively abundant adult cells of 1 type may be converted into other, therapeutically relevant cell types. Importantly, the investigators used a new genetic strategy that allowed them to avoid first converting the pancreatic exocrine cells into a primitive, stem cell–like state before turning them into insulin-secreting cells.

First Page Preview View Large
First page PDF preview
First page PDF preview