To the Editors: The Editorial by Dr Chan,1 which accompanied the randomized trial of use of Hypericum perforatum (St John's wort) for attention-deficit/hyperactivity disorder in children and adolescents by Dr Weber and colleagues,2 summarized the need for rigorous research on complementary and alternative medicine (CAM) interventions. It provided insights into some of the challenges in performing high-quality CAM research.
Stoney CM, Coates P, Briggs JP. Integrity of Active Components of Botanical Products Used in Complementary and Alternative Medicine. JAMA. 2008;300(17):1995-1996. doi:10.1001/jama.2008.557