To the Editor: Dr Chan and colleagues1 studied the association between self-reported family history of colorectal cancer and survival in a cohort of patients with stage III colorectal cancer receiving adjuvant chemotherapy. Their conclusions were that cancer recurrence was lower and survival greater in patients with a positive family history. We believe that a flawed study design precludes reaching these conclusions.
van Rossum LGM, van Oijen MGH, Jansen JBMJ. Family History and Survival in Patients With Stage III Colorectal Cancer. JAMA. 2008;300(17):1996-1997. doi:10.1001/jama.2008.547