To the Editor: Dr Trock and colleagues1 analyzed the effect of salvage treatment after radical prostatectomy on prostate cancer–specific survival. They concluded that “these results could motivate a clinical trial comparing adjuvant with salvage radiotherapy, with prostate cancer–specific survival and overall survival as the primary end points.” The recently opened RADICALS (Radiotherapy and Androgen Deprivation in Combination After Local Surgery) trial2 (ISRCTN40814031) is currently addressing this issue.
Parker C, Sydes M. Adjuvant Radiotherapy After Surgery for Prostate Cancer. JAMA. 2008;300(18):2119. doi:10.1001/jama.2008.562