To the Editor: The cohort study by Dr Limaye and colleagues1 evaluated reactivation of cytomegalovirus (CMV) infection in critically ill patients. The study used the current generation of extremely sensitive DNA amplification tests for the detection of CMV reactivation in patients who did not have traditional reasons to be immunosuppressed. Although the findings provided the rationale for further investigation, we believe there are aspects of this study that require further research to better understand the implications of the findings.
Peppercorn A, Serody J, Cairns B. Reactivation of Cytomegalovirus Infection in Critically Ill Immunocompetent Patients. JAMA. 2008;300(20):2367-2368. doi:10.1001/jama.2008.696