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Comment & Response
February 19, 2014

Short-Acting β-Blocker Administration in Patients With Septic Shock

Author Affiliations
  • 1School of Medicine, Paris Descartes University, Paris, France
JAMA. 2014;311(7):736-737. doi:10.1001/jama.2014.318

To the Editor In a recent article, Dr Morelli and colleagues1 reported a benefit of continuous esmolol infusion in patients with septic shock. In this study, administration of esmolol titrated to maintain heart rate between 80/min and 94/min was associated with a reduction of norepinephrine and fluid requirements and a decrease in mortality (28-day mortality of 80.5% in the control group vs 49.4% in the esmolol group). Because the number of patients was limited, generalization of these results should be questioned before using esmolol in the treatment of patients with septic shock.

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