To the Editor In a recent article, Dr Morelli and colleagues1 reported a benefit of continuous esmolol infusion in patients with septic shock. In this study, administration of esmolol titrated to maintain heart rate between 80/min and 94/min was associated with a reduction of norepinephrine and fluid requirements and a decrease in mortality (28-day mortality of 80.5% in the control group vs 49.4% in the esmolol group). Because the number of patients was limited, generalization of these results should be questioned before using esmolol in the treatment of patients with septic shock.
Bouglé A, Mira J. Short-Acting β-Blocker Administration in Patients With Septic Shock. JAMA. 2014;311(7):736–737. doi:10.1001/jama.2014.318