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Comment & Response
February 19, 2014

Short-Acting β-Blocker Administration in Patients With Septic Shock—Reply

Author Affiliations
  • 1Department of Anesthesiology and Intensive Care, University of Rome, “La Sapienza,” Rome, Italy
  • 2Department of Anesthesiology, Intensive Care, and Pain Medicine, University of Muenster, Muenster, Germany
  • 3Bloomsbury Institute of Intensive Care Medicine, University College London, London, England
JAMA. 2014;311(7):737-738. doi:10.1001/jama.2014.327

In Reply Dr Cortés and colleagues criticize the use of AUC in analyzing differences between groups due to potential baseline imbalances. However, imbalances were minimal and because AUC was calculated relative to baseline, any potential imbalance would have been adequately reflected. A linear mixed-effects model produced similar results. We concur that small differences in stroke volume and stroke work index should not be overinterpreted; however, the key message is that esmolol enabled heart rate control without deterioration of these variables.

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