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In Reply Dr Cortés and colleagues criticize the use of AUC in analyzing differences between groups due to potential baseline imbalances. However, imbalances were minimal and because AUC was calculated relative to baseline, any potential imbalance would have been adequately reflected. A linear mixed-effects model produced similar results. We concur that small differences in stroke volume and stroke work index should not be overinterpreted; however, the key message is that esmolol enabled heart rate control without deterioration of these variables.
Morelli A, Ertmer C, Singer M. Short-Acting β-Blocker Administration in Patients With Septic Shock—Reply. JAMA. 2014;311(7):737-738. doi:10.1001/jama.2014.327