To the Editor: In their study of the North American Silver-Coated Endotracheal Tube (NASCENT) randomized trial, Dr Kollef and colleagues1 concluded that silver-coated endotracheal tubes reduced the incidence of ventilator-associated pneumonia (VAP) by 36% compared with uncoated tubes. The evidence they present, however, is more suggestive of an effect on endobronchial colonization than on clinically meaningful invasive disease.
Klompas M. Silver-Coated Endotracheal Tubes and Patient Outcomes in Ventilator-Associated Pneumonia. JAMA. 2008;300(22):2605-2606. doi:10.1001/jama.2008.760