Evidence that angiogenesis, the development of new blood vessels, is important for tumor progression prompted interest in drugs that inhibit angiogenesis-promoting proteins, such as vascular endothelial growth factor (VEGF). Now, however, researchers from the University of California, San Diego, in La Jolla, have discovered VEGF-blocking drugs may actually accelerate tumor cell growth (Stockmann C et al. Nature. doi:10.1038/nature07445 [published online ahead of print November 9, 2008]).
Hildreth CJ. Angiogenesis and Cancer. JAMA. 2009;301(1):26. doi:10.1001/jama.2008.924