To the Editor: Cigarette smoking increases the risk of complications of Graves disease, such as ophthalmopathy and relapse after treatment with antithyroid drugs.1 Anecdotally, patients with Graves disease who smoke appear to respond more slowly to treatment with carbimazole. We therefore retrospectively compared the decline in concentrations of thyroid-stimulating hormone (TSH)–receptor antibody and thyroid hormones in smokers and nonsmokers during carbimazole therapy.
Thyroid-Stimulating Hormone–Receptor Antibody and Thyroid Hormone Concentrations in Smokers vs Nonsmokers With Graves Disease Treated With Carbimazole. JAMA. 2009;301(2):162-164. doi:10.1001/jama.2008.931