Findings from 2 double-blind, randomized trials in Africa demonstrate that a new malaria vaccine is effective at preventing both infection and the mosquito-borne disease itself in infants and children.
In one study, 894 children 5 to 17 months of age in Kenya and Tanzania were randomly assigned to receive 3 doses of the RTS, S/AS01E malaria vaccine or a control vaccine (for rabies), 809 of whom completed the study. Of the 402 assigned to receive the malaria vaccine, 32 developed clinical malaria vs 66 of 407 who received the rabies vaccine, a 53% reduction in risk (Bejon P et al. N Engl J Med. 2008;359:2521-2532).
Stephenson J. Promising Malaria Vaccine. JAMA. 2009;301(3):263. doi:10.1001/jama.2008.960