To the Editor: Dr Brar and colleagues1 studied the use of sodium bicarbonate to prevent CIN. If effective, sodium bicarbonate would be a readily available, inexpensive, and safe means to prevent a common iatrogenic cause of renal damage. In interpreting this study, several aspects of the design introduced differences between the intervention and control groups beyond the type of fluid administered.
Shy BD, Gupta A, Hoffman RS. Sodium Bicarbonate vs Sodium Chloride in Preventing Contrast Medium–Induced Nephropathy. JAMA. 2009;301(4):377-380. doi:10.1001/jama.2009.17