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Letters
January 28, 2009

Sodium Bicarbonate vs Sodium Chloride in Preventing Contrast Medium–Induced Nephropathy

JAMA. 2009;301(4):377-380. doi:10.1001/jama.2009.17

To the Editor: Dr Brar and colleagues1 studied the use of sodium bicarbonate to prevent CIN. If effective, sodium bicarbonate would be a readily available, inexpensive, and safe means to prevent a common iatrogenic cause of renal damage. In interpreting this study, several aspects of the design introduced differences between the intervention and control groups beyond the type of fluid administered.

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