To the Editor: Clinically meaningful cytomegalovirus (CMV) infection is not limited to immunocompromised hosts,1 as recently demonstrated in critically ill immunocompetent patients.2 Cytomegalovirus may have an increasing effect in an aging society. Cross-sectional analyses have shown its association with frailty and functional impairment3,4 and, along with seropositivity to other herpesviruses, an association with impaired cognition among community-dwelling older individuals.5 We therefore prospectively studied the association between CMV IgG levels and mortality.
Cytomegalovirus Antibody Level and Mortality Among Community-Dwelling Older Adults With Stable Cardiovascular Disease. JAMA. 2009;301(4):380-382. doi:10.1001/jama.2009.4