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Lab Reports
February 4, 2009

Recycling Woes

JAMA. 2009;301(5):477. doi:10.1001/jama.2009.42

A cellular mechanism that involves the recycling of cell substances and protects cells against degeneration may, when it is disrupted, play a role in Parkinson disease, according to researchers at Emory University School of Medicine in Atlanta.

The presence of aggregates of a protein implicated in Parkinson disease, alpha-synuclein, in lesions called Lewy bodies in patients with the disorder has suggested that there is a problem with protein recycling and waste disposal in Parkinson disease. But until now a mechanism underlying this disruption hasn't been clear.

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