Author Affiliations: Departments of Pediatrics, Microbiology, Medicine, and Neurosurgery, The University of Alabama at Birmingham (Dr Whitley); and Departments of Medicine, Pediatrics, and Microbiology, The University of Alabama at Birmingham and Birmingham VA Medical Center (Dr Gnann).
Drugs that inhibit tumor necrosis factor α (TNF-α) are now widely used for management of a variety of inflammatory processes (eg, rheumatologic disorders, inflammatory bowel diseases) proven refractory to conventional therapy. As with many medical advances, benefit comes with a price, and an important consequence of anti–TNF-α therapy is increased risk of infection, especially tuberculosis.1 Other studies have linked anti–TNF-α therapy with increased risk of serious bacterial2 and fungal3 infections. Associations between TNF-α antagonists and viral infections have not been as clearly defined, though case reports of severe episodes of herpes zoster in patients receiving these drugs have appeared in the literature.4 Prior analyses of large databases have yielded conflicting results regarding a causal association between treatment with biologic agents and herpes zoster.5,6
Whitley RJ, Gnann JW. Herpes Zoster in the Age of Focused Immunosuppressive Therapy. JAMA. 2009;301(7):774-775. doi:10.1001/jama.2009.150