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The World in Medicine
February 18, 2009

Heart Risk in South Asians

JAMA. 2009;301(7):712. doi:10.1001/jama.2009.167

About 4% of persons of South Asian ancestry have a genetic variant associated with an increased risk of cardiomyopathy, an international team of researchers has found (Dhandapany PS et al. Nat Genet. 10.1038/ng.309 [published online ahead of print January 18, 2009]).

In a case-control study involving about 1500 individuals from India (800 patients with cardiomyopathy and about 700 controls), the investigators found a mutation in the gene encoding cardiac myosin binding protein C increases cardiomyopathy risk by about 7 times.

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