[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.175.236. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
Quick Uptakes
April 22/29, 1998

Hormonal Manipulation

Author Affiliations
 

Not Available

Not Available

JAMA. 1998;279(16):1249. doi:10.1001/jama.279.16.1249-JQU80001-5-1

Manipulation of 2 key hormones may help women receiving fertility treatment to conceive and carry a single fetus.

In a preliminary new finding, a fertility specialist at the State University of New York at Buffalo School of Medicine and Biomedical Sciences has reported that pregnancy can occur when administration of follicle-stimulating hormone (FSH) is replaced by luteinizing hormone (LH) after a single follicle has matured.

In a study of 24 women, Michael Sullivan, MD, and his colleagues artificially stopped the subjects' production of fertility hormones and then stimulated follicle development with recombinant FSH. After a mature follicle was identified by ultrasound, the women were randomized to 1 of 4 groups: continued FSH, FSH replaced with saline, FSH replaced with high-dose recombinant LH, or FSH replaced with low-dose recombinant LH. Pregnancies resulted in all but the saline group.

First Page Preview View Large
First page PDF preview
First page PDF preview
×