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Quick Uptakes
April NaN, 1998

Hormonal Manipulation

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JAMA. 1998;279(16):1249. doi:10.1001/jama.279.16.1249-JQU80001-5-1

Manipulation of 2 key hormones may help women receiving fertility treatment to conceive and carry a single fetus.

In a preliminary new finding, a fertility specialist at the State University of New York at Buffalo School of Medicine and Biomedical Sciences has reported that pregnancy can occur when administration of follicle-stimulating hormone (FSH) is replaced by luteinizing hormone (LH) after a single follicle has matured.

In a study of 24 women, Michael Sullivan, MD, and his colleagues artificially stopped the subjects' production of fertility hormones and then stimulated follicle development with recombinant FSH. After a mature follicle was identified by ultrasound, the women were randomized to 1 of 4 groups: continued FSH, FSH replaced with saline, FSH replaced with high-dose recombinant LH, or FSH replaced with low-dose recombinant LH. Pregnancies resulted in all but the saline group.

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