Researchers from Chile and the United States have reported on a way to bring effective vaccination against Haemophilus influenzae type B (Hib) to children in developing countries at reduced cost.
Because the standard—and most costly—method of Hib vaccination is a 3-dose regimen, the researchers wanted to determine if fractional doses or a 2-dose series would offer adequate protection. They randomly assigned 627 Chilean infants to receive 3 full doses, 3 doses of one half or one third of the full dose, or 2 full doses.
Voelker R. Lowering Vaccine Costs. JAMA. 1998;279(22):1771. doi:10.1001/jama.279.22.1771-JWM80003-4-1