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June 24, 1998

Diagnosing Chorioamnionitis

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JAMA. 1998;279(24):1939. doi:10.1001/jama.279.24.1939-JQU80003-3-1

Physicians should test for chorioamnionitis in the presence of just 1 clinical sign of the condition, rather than the traditional 3, according to a new study.

Chorioamnionitis is associated with premature rupture of the fetal membrane and premature delivery, which are independent risk factors for fetal death. In a review of records of 804 perinatal deaths at Children's Hospital in Buffalo, NY, between 1988 and 1996, researchers at the State University of New York at Buffalo School of Medicine and Biomedical Sciences found that chorioamnionitis was present in about one third of the deaths.

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