Higher blood levels of damaging free radicals may result in obstruction of the pulmonary airways.
In one of the first studies to examine the relationship between lung function and oxidative stress caused by oxygen-reactive species, researchers at the State University of New York at Buffalo School of Medicine and Biomedical Sciences assessed lung function in 132 nonsmoking subjects aged 37 to 73 years. The researchers measured the volume of air the subjects could force from their lungs during a 1-second expiration, blood levels of thiobarbituric acid–reactive substances (TBARS) that are a marker of oxidative stress, and several potential antioxidants, including red blood cell glutathione, glutathione peroxidase, and serum bilirubin.
Voelker R. Oxidants Impair Lung Function. JAMA. 1998;279(4):262. doi:10.1001/jama.279.4.262-JQU71030-5-1