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The World in Medicine
February 11, 1998

Genes Affect Drug Response

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JAMA. 1998;279(6):420. doi:10.1001/jama.279.6.420-JWM81008-4-1

In a study that could further the understanding of antipsychotic drug action, researchers at the Institute of Psychiatry at the University of London in London, England, have identified an association between genetic variations in serotonin receptors and patient response to clozapine.

The researchers conducted genotype testing on 2 groups of patients. The first group consisted of 160 patients with diagnosed schizophrenia who did not respond to 2 other medications but had been treated with clozapine for 3 months. In the group, 58 were classified as nonresponders to clozapine. The second sample, chosen for replication studies of previous findings, consisted of 114 clozapine-treated patients, including 35 nonresponders.

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