Harriet S.MeyerMD, Contributing EditorJonathan D.EldredgeMLS, PhD, Journal Review EditorRobertHoganMD, adviser for new media
The first edition of this text in 1973 totally altered gastrointestinal teaching and patient care, for it was heavily based on the most current pathophysiological science, then physiology. Prominent clinician investigators contributed most of the chapters, and the editorial approach emphasized basic science–based diagnosis and treatment. No text in English was comparable.
In the ensuing years, the cutting edge of basic science has shifted from physiology to biochemistry to molecular biology and genetics. Clinical science has given increasing credence to blind, randomized, controlled trials and meta-analysis and less to actual experience. With these changes in gastroenterology and the appearance of outstanding competing texts, there have been large changes in Sleisenger and Fordtran. The greatest change came in the fifth edition of 1993, when two new editors, Bruce Scharschmidt and Mark Feldman, were added, and, as a result, the pathophysiology portions were refocused on the current science of molecular biology. The fifth edition also saw the largest change in authorship and a color atlas of endoscopic and other findings at the front of the text.
GastroenterologySleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. JAMA. 1998;279(9):715-716. doi:10.1001/jama.279.9.715-JBK0304-3-1