Scientists have found a biological mechanism that may explain why chemotherapy is more effective when given at certain times of the day.
Previous evidence had suggested the circadian clock plays a role. In the current study, researchers from the University of North Carolina in Chapel Hill demonstrated how a specific DNA-repair mechanism regulated by the clock may explain the phenomenon (Kang T et al. Proc Natl Acad Sci U S A. 10.1073/pnas.0812638106 [published online ahead of print January 21, 2009]).
Kuehn BM. Timing Chemotherapy. JAMA. 2009;301(9):924. doi:10.1001/jama.2009.243