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March 4, 2009

Valve Calcification and Patients With Bicuspid Aortic Valves—Reply

JAMA. 2009;301(9):935-936. doi:10.1001/jama.2009.119

In Reply: We are unable to address Mr Song's question about the extent of aortic valve calcification and whether it was predictive of primary cardiac events because valvular calcification was not examined in our study. However, a recent study of patients with a normal or minimally dysfunctional bicuspid valve was apparently the first to report the prognostic role of an index of aortic valve degeneration that incorporated the extent of valve thickening, calcification, and mobility.1 While the extent of valvular calcification has been shown to independently predict outcomes in asymptomatic older adults with severe aortic stenosis,2 valve calcification may be only one of several factors that predict outcomes in younger patients with bicuspid aortic valve.

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