To the Editor: In their trial of treatment to prevent atrial fibrillation, Dr Ahmed and colleagues1 reported more atrial fibrillation recurrences, all-cause mortality, and bleeding complications in patients with atrial fibrillation undergoing electrical cardioversion who were randomized to receive episodic amiodarone treatment compared with those who received continuous treatment. However, there are several issues that may have affected the validity of the conclusions.
Santangeli P, Dello Russo A, Bellocci F. Treatment With Amiodarone to Prevent Atrial Fibrillation. JAMA. 2009;301(10):1019-1020. doi:10.1001/jama.2009.262