A new technology developed by researchers at Massachusetts General Hospital in Boston links antibodies against particular proteins to unique fluorescent DNA sequences, or “bar codes,” to allow for simultaneous analysis of hundreds of cancer-related proteins at the single-cell level (Ullal AV et al. Sci Transl Med. 2014;6:219ra9). After such an antibody binds to a cell, exposure to light causes release of the unique DNA bar code, which can then be detected by imaging methods.
Hampton T. Bar Code Technology Enables Cancer Cell Protein Analysis. JAMA. 2014;311(9):894. doi:10.1001/jama.2014.1871