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Comment & Response
March 5, 2014

Deaths and Cardiovascular Events in Men Receiving Testosterone

Author Affiliations
  • 1Department of Pharmacy Practice, University of Mississippi School of Pharmacy, Jackson
  • 2Department of Pharmacy Practice, University of Connecticut, Storrs
  • 3Division of Endocrinology, University of Mississippi Medical Center, Jackson
JAMA. 2014;311(9):963-964. doi:10.1001/jama.2014.386

To the Editor A retrospective cohort study by Dr Vigen and colleagues1 evaluated the association between testosterone therapy for men with total testosterone levels of less than 300 ng/dL and a composite outcome (all-cause mortality, myocardial infarction, and stroke). Flaws in the design and population of this study may have affected the validity of the conclusions drawn by Vigen et al.1

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