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Letters
March 25, 2009

Silicone Breast Implants and Anaplastic Large T-Cell Lymphoma

JAMA. 2009;301(12):1227. doi:10.1001/jama.2009.279

To the Editor: In a case-control study, Dr de Jong and colleagues1 reported a possible association between silicone breast implants and anaplastic large T-cell lymphoma (ALCL). Although histological material of breast lymphomas was retrieved and additional immunohistochemistry and molecular studies were performed, the authors did not report on the presence of foreign bodies and foreign body reactions adjacent to the breast lymphomas. Apart from leakage and rupture, silicone gel can migrate through the intact silicone elastomer shell, a process that is called bleeding.2

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