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April 1, 2009

Triglycerides, Depression, and Risk of Ischemic Stroke

JAMA. 2009;301(13):1338-1339. doi:10.1001/jama.2009.410

To the Editor: In their prospective cohort study, Dr Freiberg and colleagues1 found that patients with elevated nonfasting triglyceride levels had an increased adjusted relative risk for ischemic stroke. The estimation of the hazard ratio was performed using Cox regression adjusted for age, sex, and other major cardiovascular risk factors such as hypertension, total cholesterol level, and smoking. However, depression as a risk factor was not included in the multivariate model, although some studies have demonstrated an association between stroke and mood disorders.2

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